Standard Name	DDI1
Systematic Name	YER143W
Alias	VSM1
Feature Type	ORF, Verified
Description	DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains (1, 2, 3, 4)
Name Description	DNA Damage Inducible 5

Chromosomal Location	ChrV:456319 to 457605 | ORF Map | GBrowse

	View Computational GO annotations for DDI1
Molecular Function
Manually curated	aspartic-type endopeptidase activity (ISA) SNARE binding (IDA) ubiquitin binding (IDA)
Biological Process
Manually curated	protein secretion (IMP) ubiquitin-dependent protein catabolic process (IMP) vesicle-mediated transport (IGI, IMP)
Cellular Component
Manually curated	plasma membrane (IDA)

Classical genetics
null	protein secretion: increased HO accumulation: abnormal
Large-scale survey
null	competitive fitness: increased resistance to benzo[a]pyrene: increased stress resistance: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	83 total interaction(s) for 40 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-Western: 27 Biochemical Activity: 1 Co-crystal Structure: 1 Co-fractionation: 1 Reconstituted Complex: 5 Two-hybrid: 12
Genetic Interactions	Dosage Growth Defect: 3 Dosage Rescue: 3 Negative Genetic: 14 Phenotypic Enhancement: 4 Phenotypic Suppression: 1 Positive Genetic: 2 Synthetic Growth Defect: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:456319 to 457605 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1287 456319..457605 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000945