DDC1/YPL194W Summary Help

DDC1 BASIC INFORMATION

Standard Name DDC1 1
Systematic Name YPL194W
Feature Type ORF, Verified
Description DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate (2, 3, 4)
Name Description DNA Damage Checkpoint 1
GO Annotations All DDC1 GO evidence and references
    View Computational GO annotations for DDC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All DDC1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions DDC1 All interactions details and references
  View additional details at BioGRID
251 total interaction(s) for 128 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 7
  • Biochemical Activity: 4
  • Co-fractionation: 2
  • Co-localization: 3
  • PCA: 2
  • Reconstituted Complex: 3
  • Two-hybrid: 6
Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Lethality: 1
  • Dosage Rescue: 5
  • Negative Genetic: 118
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 3
  • Positive Genetic: 11
  • Synthetic Growth Defect: 35
  • Synthetic Lethality: 41
  • Synthetic Rescue: 1
Sequence Information
ChrXVI:179276 to 181114 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1839 179276..181114 1996-07-31 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000006115

DDC1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for DDC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DDC1]

1) Longhese MP, et al.  (1997) The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast. EMBO J 16(17):5216-26
2) Hong EJ and Roeder GS  (2002) A role for Ddc1 in signaling meiotic double-strand breaks at the pachytene checkpoint. Genes Dev 16(3):363-76
3) Wang H and Elledge SJ  (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304
4) Giannattasio M, et al.  (2003) Correlation between checkpoint activation and in vivo assembly of the yeast checkpoint complex Rad17-Mec3-Ddc1. J Biol Chem 278(25):22303-8