DCR2/YLR361C Summary Help

Standard Name DCR2 1
Systematic Name YLR361C
Feature Type ORF, Verified
Description Phosphoesterase; involved in downregulation of the unfolded protein response (UPR), at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START (1, 2)
Name Description Dose-dependent Cell cycle Regulator 1
Chromosomal Location
ChrXII:849124 to 847388 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All DCR2 GO evidence and references
  View Computational GO annotations for DCR2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
dominant negative
null
overexpression
unspecified
Large-scale survey
null
overexpression
Resources
87 total interaction(s) for 63 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 2
  • Biochemical Activity: 2

Genetic Interactions
  • Negative Genetic: 58
  • Phenotypic Enhancement: 4
  • Positive Genetic: 4
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 13

Resources
Expression Summary
histogram
Resources
Length (a.a.) 578
Molecular Weight (Da) 66,463
Isoelectric Point (pI) 5.75
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:849124 to 847388 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1737 849124..847388 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004353
References cited on this page View Complete Literature Guide for DCR2
1) Pathak R, et al.  (2004) Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae. Eukaryot Cell 3(6):1627-38
2) Guo J and Polymenis M  (2006) Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae. EMBO Rep 7(11):1124-7