DCP1/YOL149W Summary Help

Standard Name DCP1 1
Systematic Name YOL149W
Alias MRT2 2
Feature Type ORF, Verified
Description Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress (1, 3, 4, 5, 6)
Name Description mRNA DeCaPping 1
Chromosomal Location
ChrXV:44938 to 45633 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All DCP1 GO evidence and references
  View Computational GO annotations for DCP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
null
Large-scale survey
null
reduction of function
Resources
110 total interaction(s) for 65 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 20
  • Affinity Capture-RNA: 6
  • Affinity Capture-Western: 18
  • Biochemical Activity: 1
  • Co-purification: 1
  • PCA: 2
  • Reconstituted Complex: 4
  • Two-hybrid: 22

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 2
  • Negative Genetic: 6
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Positive Genetic: 6
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 9
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 231
Molecular Weight (Da) 26,266
Isoelectric Point (pI) 5.76
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:44938 to 45633 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..696 44938..45633 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005509
References cited on this page View Complete Literature Guide for DCP1
1) Beelman CA, et al.  (1996) An essential component of the decapping enzyme required for normal rates of mRNA turnover. Nature 382(6592):642-6
2) Hatfield L, et al.  (1996) Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae. Mol Cell Biol 16(10):5830-8
3) LaGrandeur TE and Parker R  (1998) Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme. EMBO J 17(5):1487-96
4) Vilela C, et al.  (2000) The eukaryotic mRNA decapping protein Dcp1 interacts physically and functionally with the eIF4F translation initiation complex. EMBO J 19(16):4372-82
5) Fischer N and Weis K  (2002) The DEAD box protein Dhh1 stimulates the decapping enzyme Dcp1. EMBO J 21(11):2788-97
6) She M, et al.  (2006) Crystal structure and functional analysis of Dcp2p from Schizosaccharomyces pombe. Nat Struct Mol Biol 13(1):63-70