DCC1/YCL016C Summary

DCC1 BASIC INFORMATION

Standard Name	DCC1
Systematic Name	YCL016C
Feature Type	ORF, Verified
Description	Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance (1, 2)
Name Description	Defective in sister Chromatid Cohesion

GO Annotations	All DCC1 GO evidence and references
	View Computational GO annotations for DCC1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitotic sister chromatid cohesion (IGI, IMP)
High-throughput	response to DNA damage stimulus (IMP)
Cellular Component
Manually curated	Ctf18 RFC-like complex (IPI)

Mutant Phenotype	All DCC1 Phenotype details and references
Classical genetics
null	chromosome segregation: abnormal chromosome/plasmid maintenance: abnormal colony sectoring: increased resistance to hydroxyurea: decreased resistance to bortezomib: decreased resistance to camptothecin: decreased resistance to benomyl: decreased
Large-scale survey
null	budding index: increased cell size: increased competitive fitness: decreased dessication resistance: decreased fermentative growth: decreased rate heat sensitivity: increased resistance to hydroxyurea: decreased resistance to methyl methanesulfonate: decreased resistance to cisplatin: decreased resistance to doxorubicin: decreased resistance to camptothecin: decreased resistance to benomyl: decreased resistance to rapamycin: decreased telomere length: decreased toxin resistance: decreased viable

Interactions	DCC1 All interactions details and references
	View additional details at BioGRID
	527 total interaction(s) for 254 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-Western: 1 PCA: 1 Reconstituted Complex: 1
Genetic Interactions	Negative Genetic: 195 Phenotypic Enhancement: 5 Phenotypic Suppression: 2 Positive Genetic: 16 Synthetic Growth Defect: 187 Synthetic Lethality: 114

Sequence Information

ChrIII:95763 to 94621 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2006-01-12 | Sequence: 2000-09-13

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1143	95763..94621	2006-01-12	2000-09-13

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000521

DCC1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for DCC1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DCC1]

1)	Mayer ML, et al. (2001) Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell 7(5):959-70
2)	Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63

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