DBF2/YGR092W Summary Help

DBF2 BASIC INFORMATION

Standard Name DBF2
Systematic Name YGR092W
Feature Type ORF, Verified
Description Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis (1, 2, 3)
Name Description DumbBell Forming 4
GO Annotations All DBF2 GO evidence and references
    View Computational GO annotations for DBF2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: cellcycle ( 329 , 233 )
Mutant Phenotype All DBF2 Phenotype details and references
Classical genetics
null
reduction of function
Large-scale survey
null
Interactions DBF2 All interactions details and references
248 total interaction(s) for 171 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 30
  • Affinity Capture-Western: 6
  • Biochemical Activity: 89
  • Co-localization: 11
  • Co-purification: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 11
Genetic Interactions
  • Dosage Lethality: 2
  • Dosage Rescue: 23
  • Phenotypic Enhancement: 23
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 19
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 21
  • Synthetic Rescue: 6
Sequence Information
ChrVII:668193 to 669911 | ORF Map | GBrowse
Gbrowse
Genetic position: 28 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1719 668193..669911 2004-07-20 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003324

DBF2 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for DBF2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DBF2]

1) Toyn JH and Johnston LH  (1994) The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition. EMBO J 13(5):1103-13
2) Frenz LM, et al.  (2000) The budding yeast Dbf2 protein kinase localises to the centrosome and moves to the bud neck in late mitosis. J Cell Sci 113 Pt 19():3399-408
3) Visintin R and Amon A  (2001) Regulation of the mitotic exit protein kinases Cdc15 and Dbf2. Mol Biol Cell 12(10):2961-74
4) Johnston LH and Thomas AP  (1982) The isolation of new DNA synthesis mutants in the yeast Saccharomyces cerevisiae. Mol Gen Genet 186(3):439-44