Standard Name	DAP1 1
Systematic Name	YPL170W
Feature Type	ORF, Verified
Description	Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis (1, 2)
Name Description	DAmage resistance Protein 1

Chromosomal Location	ChrXVI:228314 to 228772 | ORF Map | GBrowse

	View Computational GO annotations for DAP1
Molecular Function
Manually curated	heme binding (IDA)
Biological Process
Manually curated	regulation of ergosterol biosynthetic process (IGI, IMP)
Cellular Component
Manually curated	endosome (IDA) membrane (ISS)

Classical genetics
null	episterol accumulation: increased lanosterol accumulation: increased petite resistance to methyl methanesulfonate: decreased resistance to itraconazole: decreased resistance to fluconazole: decreased resistance to BPS: decreased resistance to hemin and methyl methanesulfonate: normal resistance to hemin: normal utilization of iron source: decreased
unspecified	transposable element transposition: decreased
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased haploinsufficient lifespan: increased resistance to BPS: decreased resistance to methyl methanesulfonate: decreased resistance to fluconazole: decreased resistance to CTBT: decreased resistance to sirolimus: decreased resistance to hydroxyurea: increased resistance to wortmannin: normal resistance to cycloheximide: decreased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	55 total interaction(s) for 40 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 4 Co-fractionation: 3 PCA: 4
Genetic Interactions	Dosage Rescue: 4 Negative Genetic: 27 Phenotypic Suppression: 1 Positive Genetic: 5 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:228314 to 228772 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..459 228314..228772 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006091