DAM1/YGR113W Summary Help

DAM1 BASIC INFORMATION

Standard Name DAM1
Systematic Name YGR113W
Feature Type ORF, Verified
Description Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments (1, 2, 3, 4, 5, 6)
Name Description Duo1 And Mps1 interacting
GO Annotations All DAM1 GO evidence and references
    View Computational GO annotations for DAM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All DAM1 Phenotype details and references
Classical genetics
unspecified
Large-scale survey
null
Interactions DAM1 All interactions details and references
111 total interaction(s) for 46 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-Western: 10
  • Biochemical Activity: 3
  • Co-crystal Structure: 1
  • Co-fractionation: 2
  • Co-localization: 2
  • Co-purification: 5
  • PCA: 1
  • Reconstituted Complex: 15
  • Two-hybrid: 30
Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 23
  • Synthetic Rescue: 1
Sequence Information
ChrVII:718897 to 719928 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2004-07-20 | Sequence: 2001-05-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1032 718897..719928 2004-07-20 2001-05-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003345

DAM1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for DAM1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DAM1]

1) Li Y, et al.  (2002) The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev 16(2):183-97
2) Cheeseman IM, et al.  (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72
3) Courtwright AM and He X  (2002) Dam1 is the right one: phosphoregulation of kinetochore biorientation. Dev Cell 3(5):610-1
4) Miranda JJ, et al.  (2005) The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol 12(2):138-43
5) Westermann S, et al.  (2005) Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Mol Cell 17(2):277-90
6) Westermann S, et al.  (2006) The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature 440(7083):565-9