DAL81/YIR023W Summary

DAL81 BASIC INFORMATION

Standard Name	DAL81
Systematic Name	YIR023W
Alias	UGA35
Feature Type	ORF, Verified
Description	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism (1, 2)
Name Description	Degradation of Allantoin

GO Annotations	All DAL81 GO evidence and references
	View Computational GO annotations for DAL81
Molecular Function
Manually curated	specific RNA polymerase II transcription factor activity (IMP, ISS)
Biological Process
Manually curated	nitrogen utilization (IMP) regulation of transcription from RNA polymerase II promoter (IMP, ISS)
Cellular Component
Manually curated	nucleus (IC)

Regulatory Role
Binding motifs	DAL81 Transcription Factor Binding Sites and References
	GAAAATTGCGTTT

Mutant Phenotype	All DAL81 Phenotype details and references
Classical genetics
null	resistance to tunicamycin: decreased resistance to L-1,4-dithiothreitol: normal resistance to mercaptoethanol: decreased resistance to 6-azauracil: decreased utilization of nitrogen source: decreased
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased filamentous growth: decreased invasive growth: absent resistance to mycophenolic acid: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to cadmium dichloride: decreased resistance to doxorubicin: decreased resistance to nickel sulfate: increased toxin resistance: decreased viable
overexpression	filamentous growth: increased

Interactions	DAL81 All interactions details and references
	27 total interaction(s) for 27 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Biochemical Activity: 2 Two-hybrid: 4
Genetic Interactions	Phenotypic Enhancement: 7 Phenotypic Suppression: 6 Synthetic Growth Defect: 5 Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrIX:399774 to 402686 | |

Genetic position: 22 cM

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2913	399774..402686	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001462

DAL81 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for DAL81

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DAL81]

1)	Bricmont PA, et al. (1991) The DAL81 gene product is required for induced expression of two differently regulated nitrogen catabolic genes in Saccharomyces cerevisiae. Mol Cell Biol 11(2):1161-6
2)	Marzluf GA (1997) Genetic regulation of nitrogen metabolism in the fungi. Microbiol Mol Biol Rev 61(1):17-32

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