Standard Name	DAL7 1
Systematic Name	YIR031C
Alias	MLS2 2 , MSL2
Feature Type	ORF, Verified
Description	Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation (1, 2, 3)
Name Description	Degradation of Allantoin

Chromosomal Location	ChrIX:414679 to 413015 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 36.9 cM

	View Computational GO annotations for DAL7
Molecular Function
Manually curated	malate synthase activity (IDA, IMP)
Biological Process
Manually curated	allantoin catabolic process (IDA)
Cellular Component
Manually curated	cellular_component unknown (ND)

Pathways	glyoxylate cycle superpathway of TCA cycle and glyoxylate cycle

Large-scale survey
null	competitive fitness: increased haploinsufficient resistance to paromomycin: decreased resistance to cycloheximide: decreased resistance to benzo[a]pyrene: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	8 total interaction(s) for 8 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 1
Genetic Interactions	Negative Genetic: 4 Positive Genetic: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:414679 to 413015 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
	Genetic position: 36.9 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1665 414679..413015 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001470