DAD1/YDR016C Summary Help

DAD1 BASIC INFORMATION

Standard Name DAD1
Systematic Name YDR016C
Feature Type ORF, Verified
Description Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis (1, 2, 3, 4)
Name Description Duo1 And Dam1 interacting
GO Annotations All DAD1 GO evidence and references
    View Computational GO annotations for DAD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All DAD1 Phenotype details and references
Large-scale survey
conditional
null
Interactions DAD1 All interactions details and references
77 total interaction(s) for 22 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 9
  • Co-purification: 14
  • Reconstituted Complex: 3
  • Two-hybrid: 23
Genetic Interactions
  • Synthetic Lethality: 6
Sequence Information
ChrIV:478756 to 478472 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2008-06-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..285 478756..478472 2008-06-05 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002423

DAD1 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for DAD1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DAD1]

1) Enquist-Newman M, et al.  (2001) Dad1p, third component of the Duo1p/Dam1p complex involved in kinetochore function and mitotic spindle integrity. Mol Biol Cell 12(9):2601-13
2) Miranda JJ, et al.  (2005) The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol 12(2):138-43
3) Westermann S, et al.  (2005) Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Mol Cell 17(2):277-90
4) Westermann S, et al.  (2006) The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature 440(7083):565-9