CNE1/YAL058W Summary Help

Standard Name CNE1
Systematic Name YAL058W
Alias FUN48
Feature Type ORF, Verified
Description Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast (1, 2, 3, 4)
Name Description CalNExin and calreticulin homolog
Chromosomal Location
ChrI:37464 to 38972 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CNE1 GO evidence and references
  View Computational GO annotations for CNE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
null
Large-scale survey
null
Resources
260 total interaction(s) for 138 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 2
  • PCA: 1

Genetic Interactions
  • Dosage Rescue: 1
  • Negative Genetic: 170
  • Phenotypic Enhancement: 50
  • Phenotypic Suppression: 10
  • Positive Genetic: 11
  • Synthetic Growth Defect: 14
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 502
Molecular Weight (Da) 56,967
Isoelectric Point (pI) 5.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:37464 to 38972 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1509 37464..38972 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000054
References cited on this page View Complete Literature Guide for CNE1
1) Parlati F, et al.  (1995) Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus. J Biol Chem 270(1):244-53
2) Xu X, et al.  (2004) Expression and characterization of Saccharomyces cerevisiae Cne1p, a calnexin homologue. J Biochem 135(5):615-8
3) Xu X, et al.  (2004) P-domain and lectin site are involved in the chaperone function of Saccharomyces cerevisiae calnexin homologue. FEBS Lett 570(1-3):155-60
4) Kimura T, et al.  (2005) Interactions among Yeast Protein-Disulfide Isomerase Proteins and Endoplasmic Reticulum Chaperone Proteins Influence Their Activities. J Biol Chem 280(36):31438-41