CYS4/YGR155W Summary Help

CYS4 BASIC INFORMATION

Standard Name CYS4 1
Systematic Name YGR155W
Alias NHS5 2 , STR4 3 , VMA41 4
Feature Type ORF, Verified
Description Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria (1, 5, 6, 7)
Name Description CYStathionine beta-synthase
GO Annotations All CYS4 GO evidence and references
    View Computational GO annotations for CYS4
Molecular Function
Manually curated
Biological Process
Manually curated
High-throughput
Cellular Component
High-throughput
Pathways
Mutant Phenotype All CYS4 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions CYS4 All interactions details and references
45 total interaction(s) for 43 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 39
  • Affinity Capture-RNA: 1
  • Two-hybrid: 1
Genetic Interactions
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1
Sequence Information
ChrVII:798548 to 800071 | ORF Map | GBrowse
Gbrowse
Genetic position: 87.14 cM
Last Update Coordinates: 2004-07-20 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1524 798548..800071 2004-07-20 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000003387

CYS4 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
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  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CYS4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CYS4]

1) Ono B, et al.  (1988) Cysteine biosynthesis in Saccharomyces cerevisiae: mutation that confers cystathionine beta-synthase deficiency. J Bacteriol 170(12):5883-9
2) Skala J, et al.  (1995) The sequence of a 27 kb segment on the right arm of chromosome VII from Saccharomyces cerevisiae reveals MOL1, NAT2, RPL30B, RSR1, CYS4, PEM1/CHO2, NSR1 genes and ten new open reading frames. Yeast 11(14):1421-7
3) Cherest H, et al.  (1993) Cysteine biosynthesis in Saccharomyces cerevisiae occurs through the transsulfuration pathway which has been built up by enzyme recruitment. J Bacteriol 175(17):5366-74
4) Oluwatosin YE and Kane PM  (1997) Mutations in the CYS4 gene provide evidence for regulation of the yeast vacuolar H+-ATPase by oxidation and reduction in vivo. J Biol Chem 272(44):28149-57
5) Ono B, et al.  (1994) Purification and properties of Saccharomyces cerevisiae cystathionine beta-synthase. Yeast 10(3):333-9
6) Shan X and Kruger WD  (1998) Correction of disease-causing CBS mutations in yeast. Nat Genet 19(1):91-3
7) Singh S, et al.  (2009) Relative Contributions of Cystathionine {beta}-Synthase and {gamma}-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions. J Biol Chem 284(33):22457-66