CYS3/YAL012W Summary

CYS3 BASIC INFORMATION

Standard Name	CYS3
Systematic Name	YAL012W
Alias	CYI1 , FUN35 , STR1 1
Feature Type	ORF, Verified
Description	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine (2, 3, 4)
Name Description	CYStathionine gamma-lyase

GO Annotations	All CYS3 GO evidence and references
	View Computational GO annotations for CYS3
Molecular Function
Manually curated	cystathionine gamma-lyase activity (IDA, IMP)
Biological Process
Manually curated	cysteine biosynthetic process (IMP) cysteine biosynthetic process via cystathionine (IMP) cysteine metabolic process (TAS) sulfur amino acid metabolic process (TAS) transsulfuration (IMP)
High-throughput	response to drug (IMP)
Cellular Component
High-throughput	cytoplasm (IDA)

Pathways	cysteine biosynthesis from homocysteine homocysteine and cysteine interconversion homocysteine degradation superpathway of sulfur amino acid biosynthesis threonine catabolism

Mutant Phenotype	All CYS3 Phenotype details and references
Classical genetics
null	auxotrophy
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased filamentous growth: decreased invasive growth: absent metal resistance: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to selenomethionine: increased resistance to PM02734: increased respiratory growth: absent toxin resistance: decreased viable

Interactions	CYS3 All interactions details and references
	12 total interaction(s) for 12 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 2 Two-hybrid: 1
Genetic Interactions	Synthetic Growth Defect: 2 Synthetic Lethality: 1

Sequence Information

ChrI:130802 to 131986 | |

Genetic position: -16 cM

Last Update

Coordinates: 2004-07-20 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1185	130802..131986	2004-07-20	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000000010

CYS3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CYS3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CYS3]

1)	Cherest H and Surdin-Kerjan Y (1992) Genetic analysis of a new mutation conferring cysteine auxotrophy in Saccharomyces cerevisiae: updating of the sulfur metabolism pathway. Genetics 130(1):51-8
2)	Ono B, et al. (1991) Regulation of cystathionine gamma-lyase in Saccharomyces cerevisiae. Yeast 7(8):843-8
3)	Ono B, et al. (1992) Cloning and characterization of the CYS3 (CYI1) gene of Saccharomyces cerevisiae. J Bacteriol 174(10):3339-47
4)	Cherest H, et al. (1993) Cysteine biosynthesis in Saccharomyces cerevisiae occurs through the transsulfuration pathway which has been built up by enzyme recruitment. J Bacteriol 175(17):5366-74

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