Standard Name	CYK3 1
Systematic Name	YDL117W
Feature Type	ORF, Verified
Description	SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants (1, 2, 3, 4)
Name Description	CYtoKinesis 1

Chromosomal Location	ChrIV:248581 to 251238 | ORF Map | GBrowse

	View Computational GO annotations for CYK3
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	barrier septum assembly (IGI, IPI) cytokinesis (IGI, IPI)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud neck contractile ring (IDA) HICS complex (IPI)
High-throughput	cellular bud neck (IDA) cytoplasm (IDA) nucleus (IDA)

Classical genetics
null	bud neck morphology: abnormal chromosome/plasmid maintenance: abnormal cytokinesis: abnormal vegetative growth: decreased rate viable
Large-scale survey
null	anaerobic growth: decreased chitin deposition: increased competitive fitness: decreased filamentous growth: decreased haploinsufficient invasive growth: absent resistance to glucose: decreased resistance to calcium dichloride: decreased resistance to benzo[a]pyrene: decreased resistance to Loperamide: decreased resistance to 1,10-phenanthroline: decreased resistance to Azaserine: decreased resistance to magnesium dichloride: decreased resistance to sirolimus: decreased resistance to caffeine: decreased resistance to Calcofluor White: decreased resistance to tunicamycin: increased resistance to hydroxyurea: increased resistance to cycloheximide: increased resistance to cycloheximide: decreased resistance to amitrole: decreased respiratory growth: decreased rate toxin resistance: increased viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	245 total interaction(s) for 148 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-Western: 1 Biochemical Activity: 1 PCA: 9 Protein-RNA: 1 Reconstituted Complex: 3 Two-hybrid: 21
Genetic Interactions	Dosage Growth Defect: 6 Dosage Rescue: 7 Negative Genetic: 127 Phenotypic Enhancement: 3 Phenotypic Suppression: 2 Positive Genetic: 13 Synthetic Growth Defect: 28 Synthetic Lethality: 19 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIV:248581 to 251238 | ORF Map | GBrowse
Last Update	Coordinates: 2004-02-11 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2658 248581..251238 2004-02-11 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000002275