CYC3/YAL039C Summary Help

Standard Name CYC3
Systematic Name YAL039C
Feature Type ORF, Verified
Description Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS) (1, 2)
Name Description CYtochrome C
Gene Product Alias CCHL 3 , cytochrome c heme lyase 3
Chromosomal Location
ChrI:69525 to 68716 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: -47 cM
Gene Ontology Annotations All CYC3 GO evidence and references
  View Computational GO annotations for CYC3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 10 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
28 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Biochemical Activity: 4
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 2
  • Negative Genetic: 9
  • Phenotypic Enhancement: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 269
Molecular Weight (Da) 30,081
Isoelectric Point (pI) 5.26
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrI:69525 to 68716 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: -47 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..810 69525..68716 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000037
References cited on this page View Complete Literature Guide for CYC3
1) Dumont ME, et al.  (1987) Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae. EMBO J 6(1):235-41
2) Dumont ME, et al.  (1991) Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in Saccharomyces cerevisiae. Mol Cell Biol 11(11):5487-96
3) Bernard DG, et al.  (2003) Overlapping specificities of the mitochondrial cytochrome c and c1 heme lyases. J Biol Chem 278(50):49732-42