CYB5/YNL111C Summary Help

Standard Name CYB5
Systematic Name YNL111C
Feature Type ORF, Verified
Description Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation (1, 2)
Name Description CYtochrome B
Chromosomal Location
ChrXIV:417302 to 416940 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CYB5 GO evidence and references
  View Computational GO annotations for CYB5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Large-scale survey
null
overexpression
Resources
79 total interaction(s) for 62 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 5

Genetic Interactions
  • Negative Genetic: 54
  • Positive Genetic: 11
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 120
Molecular Weight (Da) 13,297
Isoelectric Point (pI) 4.18
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:417302 to 416940 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..363 417302..416940 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005055
References cited on this page View Complete Literature Guide for CYB5
1) Truan G, et al.  (1994) Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain. Gene 142(1):123-7
2) Lamb DC, et al.  (1999) Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. FEBS Lett 462(3):283-8