CYB5/YNL111C Summary

CYB5 BASIC INFORMATION

Standard Name	CYB5
Systematic Name	YNL111C
Feature Type	ORF, Verified
Description	Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation (1, 2)
Name Description	CYtochrome B

GO Annotations	All CYB5 GO evidence and references
	View Computational GO annotations for CYB5
Molecular Function
Manually curated	electron carrier activity (IDA)
Biological Process
Manually curated	sterol biosynthetic process (IDA)
Cellular Component
Manually curated	endoplasmic reticulum membrane (IDA) microsome (IDA)

Mutant Phenotype	All CYB5 Phenotype details and references
Large-scale survey
null	resistance to rapamycin: decreased resistance to wortmannin: decreased resistance to hygromycin B: decreased resistance to hydroxyurea: decreased resistance to ethanol: increased resistance to ethanol: decreased

Interactions	CYB5 All interactions details and references
	16 total interaction(s) for 13 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Two-hybrid: 5
Genetic Interactions	Phenotypic Enhancement: 6 Synthetic Growth Defect: 4

Sequence Information

ChrXIV:417304 to 416942 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..363	417304..416942	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000005055

CYB5 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CYB5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CYB5]

1)	Truan G, et al. (1994) Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain. Gene 142(1):123-7
2)	Lamb DC, et al. (1999) Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. FEBS Lett 462(3):283-8

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