CWC22/YGR278W Summary

CWC22 BASIC INFORMATION

Standard Name	CWC22 1
Systematic Name	YGR278W
Feature Type	ORF, Verified
Description	Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data (1, 2)
Name Description	Complexed With Cef1p 1

GO Annotations	All CWC22 GO evidence and references
	View Computational GO annotations for CWC22
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	nuclear mRNA splicing, via spliceosome (IC)
Cellular Component
Manually curated	U2-type spliceosomal complex (IDA)

Mutant Phenotype	All CWC22 Phenotype details and references
Large-scale survey
conditional	heat sensitivity: increased
null	inviable

Interactions	CWC22 All interactions details and references
	49 total interaction(s) for 26 unique genes/features.
Physical Interactions	Affinity Capture-MS: 39 Two-hybrid: 1
Genetic Interactions	Phenotypic Enhancement: 4 Synthetic Lethality: 5

Sequence Information

ChrVII:1046738 to 1048471 | |

Last Update

Coordinates: 2007-12-11 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1734	1046738..1048471	2007-12-11	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003510

CWC22 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CWC22

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CWC22]

1)	Ohi MD, et al. (2002) Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. Mol Cell Biol 22(7):2011-24
2)	Samanta MP and Liang S (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83

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