CWC22/YGR278W Summary Help

Standard Name CWC22 1
Systematic Name YGR278W
Feature Type ORF, Verified
Description Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein (1, 2)
Name Description Complexed With Cef1p 1
Chromosomal Location
ChrVII:1046731 to 1048464 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CWC22 GO evidence and references
  View Computational GO annotations for CWC22
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Large-scale survey
conditional
null
reduction of function
Resources
58 total interaction(s) for 35 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 45
  • Two-hybrid: 2

Genetic Interactions
  • Negative Genetic: 3
  • Phenotypic Enhancement: 1
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 577
Molecular Weight (Da) 67,293
Isoelectric Point (pI) 6.84
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:1046731 to 1048464 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1734 1046731..1048464 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003510
References cited on this page View Complete Literature Guide for CWC22
1) Ohi MD, et al.  (2002) Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. Mol Cell Biol 22(7):2011-24
2) Yeh TC, et al.  (2011) Splicing factor Cwc22 is required for the function of Prp2 and for the spliceosome to escape from a futile pathway. Mol Cell Biol 31(1):43-53