CUS2/YNL286W Summary Help

Standard Name CUS2 1
Systematic Name YNL286W
Feature Type ORF, Verified
Description Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) (1, 2)
Name Description Cold sensitive U2 snRNA Suppressor 1
Chromosomal Location
ChrXIV:95223 to 96080 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CUS2 GO evidence and references
  View Computational GO annotations for CUS2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
31 total interaction(s) for 25 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Co-purification: 1
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 1
  • Negative Genetic: 9
  • Phenotypic Suppression: 1
  • Positive Genetic: 3
  • Synthetic Growth Defect: 2
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 285
Molecular Weight (Da) 32,284
Isoelectric Point (pI) 4.73
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIV:95223 to 96080 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..858 95223..96080 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005230
References cited on this page View Complete Literature Guide for CUS2
1) Yan D, et al.  (1998) CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif. Mol Cell Biol 18(9):5000-9
2) Chathoth KT, et al.  (2014) A splicing-dependent transcriptional checkpoint associated with prespliceosome formation. Mol Cell 53(5):779-90