Standard Name	CUP2 1
Systematic Name	YGL166W
Alias	ACE1 2 , 3
Feature Type	ORF, Verified
Description	Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; CUP2 has a paralog, HAA1, that arose from the whole genome duplication (3, 4, 5)

Chromosomal Location	ChrVII:191129 to 191806 | ORF Map | GBrowse
	Genetic position: -101 cM

	View Computational GO annotations for CUP2
Molecular Function
Manually curated	copper ion binding (IDA) copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity (IDA, IMP) RNA polymerase II core promoter proximal region sequence-specific DNA binding (IDA)
Biological Process
Manually curated	regulation of transcription from RNA polymerase II promoter (IMP) response to copper ion (IMP)
Cellular Component
Manually curated	nucleus (IDA)

Regulatory modules	predicted: stressResponse (613) predicted: cellcycle (389) predicted: stressResponse (613) predicted: cellcycle (389)
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
null	metal resistance: decreased metal resistance: increased
reduction of function	CUP1-LacZ accumulation: decreased
unspecified	metal resistance: decreased
Large-scale survey
null	competitive fitness: decreased metal resistance: decreased resistance to elesclomol-Cu: decreased resistance to propolis extract: decreased vacuolar morphology: abnormal viable
overexpression	inviable silencing: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	30 total interaction(s) for 29 unique genes/features.
Physical Interactions	Affinity Capture-MS: 1 Affinity Capture-RNA: 3 Affinity Capture-Western: 1 FRET: 1 Two-hybrid: 7
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 10 Phenotypic Enhancement: 1 Positive Genetic: 4 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVII:191129 to 191806 | ORF Map | GBrowse
	Genetic position: -101 cM
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..678 191129..191806 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000003134