CUP1-1/YHR053C Summary

CUP1-1 BASIC INFORMATION

Standard Name	CUP1-1
Systematic Name	YHR053C
Alias	CUP1
Feature Type	ORF, Verified
Description	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C (1, 2)

GO Annotations	All CUP1-1 GO evidence and references
	View Computational GO annotations for CUP1-1
Molecular Function
Manually curated	copper ion binding (IDA)
Biological Process
Manually curated	response to copper ion (IMP)
Cellular Component
Manually curated	cytosol (IDA)

Mutant Phenotype	All CUP1-1 Phenotype details and references
Classical genetics
null	resistance to copper(2+): decreased resistance to cadmium(2+): decreased
overexpression	resistance to cadmium(2+): increased resistance to copper(2+): increased

Interactions	CUP1-1 All interactions details and references
	3 total interaction(s) for 2 unique genes/features.
Genetic Interactions	Dosage Rescue: 2 Phenotypic Suppression: 1

Sequence Information

ChrVIII:212722 to 212537 | |

Note: this feature is encoded on the Crick strand.

This feature is contained within: RUF5-1

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..186	212722..212537	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001095

CUP1-1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CUP1-1

REPEATED NOTE

Name	Relevance	Description
CUP1-2	Repeated	There are 2 copies of CUP1 in the genome.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CUP1-1]

1)	Winge DR, et al. (1985) Yeast metallothionein. Sequence and metal-binding properties. J Biol Chem 260(27):14464-70
2)	Karin M, et al. (1984) Primary structure and transcription of an amplified genetic locus: the CUP1 locus of yeast. Proc Natl Acad Sci U S A 81(2):337-41

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