CTI6/YPL181W Summary Help

Standard Name CTI6 1
Systematic Name YPL181W
Alias RXT1
Feature Type ORF, Verified
Description Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain (2, 3)
Name Description Cyc8-Tup1 Interacting protein 2
Chromosomal Location
ChrXVI:203421 to 204941 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CTI6 GO evidence and references
  View Computational GO annotations for CTI6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
413 total interaction(s) for 235 unique genes/features.
Physical Interactions
  • Affinity Capture-Luminescence: 4
  • Affinity Capture-MS: 66
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 11
  • Biochemical Activity: 5
  • Co-localization: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 216
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 74
  • Synthetic Growth Defect: 12
  • Synthetic Lethality: 11
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 506
Molecular Weight (Da) 57,052
Isoelectric Point (pI) 4.63
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXVI:203421 to 204941 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1521 203421..204941 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000006102
References cited on this page View Complete Literature Guide for CTI6
1) Schaft, D, et al.  (2002) personal communication
2) Papamichos-Chronakis M, et al.  (2002) Cti6, a PHD domain protein, bridges the Cyc8-Tup1 corepressor and the SAGA coactivator to overcome repression at GAL1. Mol Cell 9(6):1297-305
3) Carrozza MJ, et al.  (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim Biophys Acta 1731(2):77-87; discussion 75-6