Standard Name	CTI6 1
Systematic Name	YPL181W
Alias	RXT1
Feature Type	ORF, Verified
Description	Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain (2)
Name Description	Cyc8-Tup1 Interacting protein 2

Chromosomal Location	ChrXVI:203421 to 204941 | ORF Map | GBrowse

	View Computational GO annotations for CTI6
Molecular Function
Manually curated	methylated histone residue binding (IDA) transcription factor binding (IDA)
Biological Process
Manually curated	negative regulation of chromatin silencing at rDNA (IMP) negative regulation of chromatin silencing at silent mating-type cassette (IMP) negative regulation of chromatin silencing at telomere (IMP) positive regulation of transcription, DNA-dependent (IMP) regulation of DNA-dependent DNA replication initiation (IMP)
Cellular Component
Manually curated	nucleus (IC) Rpd3L complex (IDA)
High-throughput	Rpd3L complex (IDA) Rpd3L-Expanded complex (IDA)

Classical genetics
null	metal resistance: decreased resistance to sirolimus: increased
Large-scale survey
null	competitive fitness: increased resistance to camptothecin: decreased resistance to ethanol: decreased resistance to mycophenolic acid: decreased resistance to tunicamycin: decreased resistance to BPS: decreased resistance to hydroxyurea: increased resistance to cycloheximide: decreased resistance to doxorubicin: decreased resistance to bleomycin: increased vacuolar morphology: abnormal viable
overexpression	vegetative growth: decreased rate
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	411 total interaction(s) for 235 unique genes/features.
Physical Interactions	Affinity Capture-Luminescence: 4 Affinity Capture-MS: 65 Affinity Capture-RNA: 3 Affinity Capture-Western: 11 Biochemical Activity: 5 Co-localization: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Negative Genetic: 215 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 74 Synthetic Growth Defect: 12 Synthetic Lethality: 11 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:203421 to 204941 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1521 203421..204941 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006102