CTF18/YMR078C Summary Help

Standard Name CTF18 1
Systematic Name YMR078C
Alias CHL12 1
Feature Type ORF, Verified
Description Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint (2, 3)
Name Description Chromosome Transmission Fidelity 4
Chromosomal Location
ChrXIII:424728 to 422503 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CTF18 GO evidence and references
  View Computational GO annotations for CTF18
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
786 total interaction(s) for 353 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 23
  • Affinity Capture-Western: 18
  • Co-purification: 5
  • Reconstituted Complex: 8

Genetic Interactions
  • Dosage Growth Defect: 12
  • Dosage Lethality: 7
  • Negative Genetic: 301
  • Phenotypic Enhancement: 21
  • Phenotypic Suppression: 8
  • Positive Genetic: 21
  • Synthetic Growth Defect: 237
  • Synthetic Lethality: 123
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 741
Molecular Weight (Da) 84,373
Isoelectric Point (pI) 8.46
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:424728 to 422503 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2226 424728..422503 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004683
References cited on this page View Complete Literature Guide for CTF18
1) Kouprina N, et al.  (1993) Identification and genetic mapping of CHL genes controlling mitotic chromosome transmission in yeast. Yeast 9(1):11-9
2) Mayer ML, et al.  (2001) Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell 7(5):959-70
3) Naiki T, et al.  (2001) Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway. Mol Cell Biol 21(17):5838-45
4) Spencer F, et al.  (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124(2):237-49