CTF18/YMR078C Summary

CTF18 BASIC INFORMATION

Standard Name	CTF18
Systematic Name	YMR078C
Alias	CHL12 1
Feature Type	ORF, Verified
Description	Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint (2, 3)
Name Description	Chromosome Transmission Fidelity 4

GO Annotations	All CTF18 GO evidence and references
	View Computational GO annotations for CTF18
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	double-strand break repair via homologous recombination (IMP) mitotic sister chromatid cohesion (IGI, IMP)
Cellular Component
Manually curated	Ctf18 RFC-like complex (IPI) nuclear replication fork (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All CTF18 Phenotype details and references
Classical genetics
null	chromosome segregation: abnormal chromosome segregation: premature chromosome/plasmid maintenance: abnormal colony sectoring: increased GFP-Rap1 distribution: abnormal resistance to methyl methanesulfonate: decreased resistance to hydroxyurea: decreased resistance to phleomycin: decreased resistance to camptothecin: decreased resistance to bleomycin A2: decreased telomere length: decreased
Large-scale survey
null	glycogen accumulation: increased chromosome/plasmid maintenance: decreased competitive fitness: decreased heat sensitivity: increased resistance to amiodarone: decreased resistance to methyl methanesulfonate: decreased resistance to cisplatin: decreased resistance to benomyl: decreased viable

Interactions	CTF18 All interactions details and references
	505 total interaction(s) for 247 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-Western: 14 Co-purification: 5 Reconstituted Complex: 7
Genetic Interactions	Dosage Lethality: 6 Phenotypic Enhancement: 105 Phenotypic Suppression: 9 Synthetic Growth Defect: 208 Synthetic Lethality: 131

Sequence Information

ChrXIII:424727 to 422502 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2226	424727..422502	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004683

CTF18 RESOURCES

Click on map for expanded view

SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CTF18

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CTF18]

1)	Kouprina N, et al. (1993) Identification and genetic mapping of CHL genes controlling mitotic chromosome transmission in yeast. Yeast 9(1):11-9
2)	Mayer ML, et al. (2001) Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell 7(5):959-70
3)	Naiki T, et al. (2001) Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway. Mol Cell Biol 21(17):5838-45
4)	Spencer F, et al. (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124(2):237-49

SGD^tm pages Database Copyright © 1997-2010 The Board of Trustees of Leland Stanford Junior University. Permission to use the information contained in this database was given by the researchers/institutes who contributed or published the information. Users of the database are solely responsible for compliance with any copyright restrictions, including those applying to the author abstracts. Documents from this server are provided "AS-IS" without any warranty, expressed or implied. The SGD project at Stanford University is supported by a Genome Research Resource Grant from the US National Human Genome Research Institute, part of the US National Institutes of Health.