Standard Name	CSR2 1
Systematic Name	YPR030W
Alias	MRG19 , ART8 2
Feature Type	ORF, Verified
Description	Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description	Chs5 Spa2 Rescue 1

Chromosomal Location	ChrXVI:627880 to 631245 | ORF Map | GBrowse

	View Computational GO annotations for CSR2
Molecular Function
Manually curated	ubiquitin protein ligase binding (IPI)
Biological Process
Manually curated	fungal-type cell wall organization (IGI) regulation of transcription from RNA polymerase II promoter (IGI, IMP) ubiquitin-dependent endocytosis (ISA)
Cellular Component
Manually curated	nucleus (IDA)

Classical genetics
null	reactive oxygen species accumulation: increased chronological lifespan: increased oxidative stress resistance: decreased catalase activity: increased glutathione peroxidase activity: increased superoxide dismutase activity: increased pseudohyphal growth: decreased replicative lifespan: increased sporulation efficiency: increased
Large-scale survey
null	anaerobic growth: decreased competitive fitness: decreased endocytosis: decreased haploinsufficient resistance to fenpropimorph: decreased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to mycophenolic acid: decreased resistance to sirolimus: decreased resistance to cycloheximide: increased resistance to amiodarone: decreased resistance to nickel sulfate: decreased resistance to camptothecin: decreased resistance to bleomycin: decreased resistance to arsenite(3-): decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	43 total interaction(s) for 38 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-Western: 1 Biochemical Activity: 3 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Negative Genetic: 22 Phenotypic Enhancement: 1 Positive Genetic: 3 Synthetic Growth Defect: 2 Synthetic Lethality: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXVI:627880 to 631245 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3366 627880..631245 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000006234