Standard Name	CSR1 1
Systematic Name	YLR380W
Alias	SFH2 2
Feature Type	ORF, Verified
Description	Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress (3, 4, 5, 6)
Name Description	Chs5 Spa2 Rescue 1

Chromosomal Location	ChrXII:878282 to 879508 | ORF Map | GBrowse

	View Computational GO annotations for CSR1
Molecular Function
Manually curated	NOT phosphatidylcholine transporter activity (IDA) phosphatidylinositol transporter activity (IDA)
Biological Process
Manually curated	Golgi to plasma membrane protein transport (IGI) Golgi to plasma membrane transport (IGI) negative regulation of fatty acid biosynthetic process (IDA, IGI, IMP) negative regulation of phosphatidylglycerol biosynthetic process (IGI) phosphatidylinositol metabolic process (IGI) phospholipid transport (IDA) positive regulation of phosphatidylcholine biosynthetic process (IGI)
Cellular Component
Manually curated	cytosol (IDA) endosome (IDA) lipid particle (IDA)
High-throughput	mitochondrion (IDA)

Classical genetics
null	metal resistance: decreased
Large-scale survey
null	anaerobic growth: decreased competitive fitness: increased resistance to sirolimus: decreased sporulation: normal starvation resistance: decreased viable
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	41 total interaction(s) for 29 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 2 Protein-RNA: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 9 Negative Genetic: 12 Phenotypic Suppression: 3 Synthetic Growth Defect: 2 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:878282 to 879508 | ORF Map | GBrowse
Last Update	Coordinates: 2004-02-05 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1227 878282..879508 2004-02-05 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004372