CSM3/YMR048W Summary Help

CSM3 BASIC INFORMATION

Standard Name CSM3 1
Systematic Name YMR048W
Feature Type ORF, Verified
Description Replication fork associated factor, required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis (1, 2, 3, 4)
Name Description Chromosome Segregation in Meiosis 1
GO Annotations All CSM3 GO evidence and references
    View Computational GO annotations for CSM3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All CSM3 Phenotype details and references
Classical genetics
null
Large-scale survey
null
overexpression
Interactions CSM3 All interactions details and references
  View additional details at BioGRID
437 total interaction(s) for 203 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-Western: 11
  • Biochemical Activity: 1
  • Two-hybrid: 8
Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 159
  • Phenotypic Enhancement: 9
  • Phenotypic Suppression: 2
  • Positive Genetic: 9
  • Synthetic Growth Defect: 120
  • Synthetic Lethality: 96
  • Synthetic Rescue: 2
Sequence Information
ChrXIII:366980 to 367933 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..954 366980..367933 1996-07-31 1996-07-31
Post-translational Modifications PhosphoGRID | PhosphoPep Database
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004651

CSM3 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
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  • Phenotype Resources
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for CSM3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CSM3]

1) Rabitsch KP, et al.  (2001) A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr Biol 11(13):1001-9
2) Calzada A, et al.  (2005) Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork. Genes Dev 19(16):1905-19
3) Mohanty BK, et al.  (2006) The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 103(4):897-902
4) Bando M, et al.  (2009) Csm3, Tof1, and Mrc1 form a heterotrimeric mediator complex that associates with DNA replication forks. J Biol Chem 284(49):34355-65