CSM1/YCR086W Summary Help

Standard Name CSM1 1
Systematic Name YCR086W
Feature Type ORF, Verified
Description Nucleolar protein that mediates homolog segregation during meiosis I; forms a complex with Lrs4p and then Mam1p at kinetochores; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation (2, 3, 4)
Name Description Chromosome Segregation in Meiosis 1
Chromosomal Location
ChrIII:263392 to 263964 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CSM1 GO evidence and references
  View Computational GO annotations for CSM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 3 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
474 total interaction(s) for 281 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 33
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 13
  • Co-crystal Structure: 3
  • Co-localization: 4
  • Reconstituted Complex: 7
  • Two-hybrid: 61

Genetic Interactions
  • Negative Genetic: 194
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 7
  • Positive Genetic: 24
  • Synthetic Growth Defect: 87
  • Synthetic Lethality: 35
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 190
Molecular Weight (Da) 21,751
Isoelectric Point (pI) 4.92
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIII:263392 to 263964 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..573 263392..263964 2011-02-03 1997-01-28
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000682
References cited on this page View Complete Literature Guide for CSM1
1) Rabitsch KP, et al.  (2001) A screen for genes required for meiosis and spore formation based on whole-genome expression. Curr Biol 11(13):1001-9
2) Rabitsch KP, et al.  (2003) Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell 4(4):535-48
3) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
4) Johzuka K and Horiuchi T  (2009) The cis element and factors required for condensin recruitment to chromosomes. Mol Cell 34(1):26-35