CSI1/YMR025W Summary Help

Standard Name CSI1 1
Systematic Name YMR025W
Feature Type ORF, Verified
Description Subunit of the Cop9 signalosome; which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome (1, 2, 3)
Name Description Cop9 Signalosome Interactor 1
Chromosomal Location
ChrXIII:323300 to 324187 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CSI1 GO evidence and references
  View Computational GO annotations for CSI1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
62 total interaction(s) for 42 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Affinity Capture-RNA: 2
  • Two-hybrid: 13

Genetic Interactions
  • Negative Genetic: 12
  • Positive Genetic: 19
  • Synthetic Growth Defect: 1
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 295
Molecular Weight (Da) 34,519
Isoelectric Point (pI) 5
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:323300 to 324187 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..888 323300..324187 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004627
References cited on this page View Complete Literature Guide for CSI1
1) Maytal-Kivity V, et al.  (2002) COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. EMBO Rep 3(12):1215-21
2) Wee S, et al.  (2002) Conservation of the COP9/signalosome in budding yeast. BMC Genet 3():15
3) Pick E, et al.  (2012) The Minimal Deneddylase Core of the COP9 Signalosome Excludes the Csn6 MPN(-) Domain. PLoS One 7(8):e43980