Standard Name	CSF1
Systematic Name	YLR087C
Feature Type	ORF, Verified
Description	Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies (1, 2)
Name Description	Cold Sensitive for Fermentation 1

Chromosomal Location	ChrXII:315731 to 306855 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CSF1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	fermentation (IMP)
Cellular Component
High-throughput	mitochondrion (IDA)

Classical genetics
null	metal resistance: decreased Ptr2p-GFP distribution: abnormal Gas1p modification: decreased resistance to FK506: decreased resistance to staurosporine: decreased resistance to tunicamycin: decreased resistance to Calcofluor White: decreased resistance to chlorpromazine: decreased resistance to 1-O-hexadecyl-sn-glycerophosphocholine: decreased vegetative growth: decreased rate
overexpression	fermentative metabolism: increased rate vegetative growth: decreased rate
Large-scale survey
null	auxotrophy glycogen accumulation: increased chitin deposition: increased competitive fitness: decreased dessication resistance: decreased endocytosis: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased metal resistance: increased metal resistance: decreased nutrient utilization: decreased protein transport: abnormal resistance to streptomycin: decreased resistance to cycloheximide: decreased resistance to Calcofluor White: decreased resistance to mycophenolic acid: decreased resistance to hydrogen chloride: decreased resistance to sodium arsenite: decreased resistance to methyl methanesulfonate: decreased resistance to hygromycin B: decreased resistance to spermine: decreased resistance to bleomycin: decreased resistance to camptothecin: decreased resistance to chloroquine: decreased resistance to acetic acid: decreased respiratory growth: decreased rate toxin resistance: increased vegetative growth: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	573 total interaction(s) for 313 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-RNA: 2
Genetic Interactions	Negative Genetic: 421 Positive Genetic: 97 Synthetic Growth Defect: 28 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 22
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXII:315731 to 306855 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..8877 315731..306855 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB

Primary SGDID	S000004077