CSE1/YGL238W Summary

CSE1 BASIC INFORMATION

Standard Name	CSE1
Systematic Name	YGL238W
Alias	KAP109
Feature Type	ORF, Verified
Description	Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation (1, 2, 3)
Name Description	Chromosome SEgregation 2

GO Annotations	All CSE1 GO evidence and references
	View Computational GO annotations for CSE1
Molecular Function
Manually curated	importin-alpha export receptor activity (IGI, IPI, ISS)
Biological Process
Manually curated	protein export from nucleus (IGI, IPI)
Cellular Component
Manually curated	nuclear envelope (IDA)

Mutant Phenotype	All CSE1 Phenotype details and references
Large-scale survey
null	inviable
repressible	cell cycle progression in S phase: abnormal mitochondrial morphology: abnormal

Interactions	CSE1 All interactions details and references
	62 total interaction(s) for 39 unique genes/features.
Physical Interactions	Affinity Capture-MS: 9 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Co-crystal Structure: 1 Reconstituted Complex: 7 Two-hybrid: 11
Genetic Interactions	Dosage Rescue: 3 Phenotypic Enhancement: 10 Phenotypic Suppression: 9 Synthetic Growth Defect: 4 Synthetic Lethality: 1 Synthetic Rescue: 1

Sequence Information

ChrVII:49552 to 52434 | |

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2883	49552..52434	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003207

CSE1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CSE1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CSE1]

1)	Schroeder AJ, et al. (1999) Genetic evidence for interactions between yeast importin alpha (Srp1p) and its nuclear export receptor, Cse1p. Mol Gen Genet 261(4-5):788-95
2)	Xiao Z, et al. (1993) CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae. Mol Cell Biol 13(8):4691-702
3)	Hood JK and Silver PA (1998) Cse1p is required for export of Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae. J Biol Chem 273(52):35142-6

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