Standard Name	CRZ1 1
Systematic Name	YNL027W
Alias	HAL8 2 , TCN1 1 , 3
Feature Type	ORF, Verified
Description	Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress (1, 3, 4, 5)
Name Description	Calcineurin-Responsive Zinc finger 1

Chromosomal Location	ChrXIV:579580 to 581616 | ORF Map | GBrowse

	View Computational GO annotations for CRZ1
Molecular Function
Manually curated	core promoter proximal region sequence-specific DNA binding (IDA) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (IDA)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	cell wall chitin biosynthetic process (IGI) cellular response to blue light (IDA) ion homeostasis (IGI, IMP) positive regulation of cellular response to drug (IMP) positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter (IDA) positive regulation of transcription from RNA polymerase II promoter (IGI, IMP) positive regulation of transcription from RNA polymerase II promoter by calcium-mediated signaling (IGI, IMP) positive regulation of transcription from RNA polymerase II promoter by pheromones (IMP) positive regulation of transcription from RNA polymerase II promoter in response to alkalinity (IMP) positive regulation of transcription from RNA polymerase II promoter in response to calcium ion (IMP) positive regulation of transcription from RNA polymerase II promoter in response to increased salt (IMP) regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter (IDA, IGI, IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Binding motifs	VMGCCHC 6 [Search intergenic regions for VMGCCHC]
Regulatory modules	predicted: cellcycle (371, 365, 215)
Resources	ScerTF | YEASTRACT | YeTFaSCo

Classical genetics
null	pheromone sensitivity: increased resistance to Plakortide F Acid: decreased resistance to manganese(2+): decreased resistance to sodium(1+): decreased resistance to calcium(2+): decreased resistance to lithium(1+): decreased resistance to quinine: decreased
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased haploinsufficient hyperosmotic stress resistance: decreased ionic stress resistance: decreased metal resistance: decreased resistance to fenpropimorph: increased resistance to amitrole: decreased resistance to neomycin: decreased resistance to fluconazole: increased resistance to camptothecin: decreased resistance to caffeine: decreased resistance to cycloheximide: decreased resistance to L-1,4-dithiothreitol: decreased resistance to calcium dichloride: decreased resistance to tunicamycin: decreased stress resistance: decreased toxin resistance: decreased toxin resistance: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	123 total interaction(s) for 101 unique genes/features.
Physical Interactions	Affinity Capture-MS: 6 Affinity Capture-RNA: 1 Affinity Capture-Western: 4 Biochemical Activity: 20 PCA: 2 Reconstituted Complex: 10 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 1 Dosage Rescue: 4 Negative Genetic: 54 Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Positive Genetic: 6 Synthetic Growth Defect: 4 Synthetic Lethality: 2 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:579580 to 581616 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2037 579580..581616 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004972