CRZ1/YNL027W Summary

CRZ1 BASIC INFORMATION

Standard Name	CRZ1
Systematic Name	YNL027W
Alias	HAL8 , TCN1
Feature Type	ORF, Verified
Description	Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation (1, 2, 3)
Name Description	Calcineurin-Responsive Zinc finger 1

GO Annotations	All CRZ1 GO evidence and references
	View Computational GO annotations for CRZ1
Molecular Function
Manually curated	transcription factor activity (IDA, IPI, ISS)
High-throughput	sequence-specific DNA binding (IDA)
Biological Process
Manually curated	calcium-mediated signaling (IGI, IMP, IPI) regulation of transcription, DNA-dependent (IMP)
Cellular Component
Manually curated	cytoplasm (IDA) nucleus (IDA)

Regulatory Role
Regulatory modules	predicted: cellcycle ( 371 , 365 , 215 )

Mutant Phenotype	All CRZ1 Phenotype details and references
Classical genetics
null	pheromone sensitivity: increased resistance to manganese(2+): decreased resistance to sodium(1+): decreased resistance to calcium(2+): decreased resistance to lithium(1+): decreased resistance to quinine: decreased
Large-scale survey
null	alkaline pH resistance: decreased competitive fitness: decreased hyperosmotic stress resistance: decreased resistance to L-1,4-dithiothreitol: decreased resistance to calcium dichloride: decreased resistance to tunicamycin: decreased viable

Interactions	CRZ1 All interactions details and references
	42 total interaction(s) for 35 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Affinity Capture-RNA: 1 Affinity Capture-Western: 3 Biochemical Activity: 23 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 1 Phenotypic Enhancement: 6 Synthetic Lethality: 2

Sequence Information

ChrXIV:579582 to 581618 | |

Last Update

Coordinates: 2010-01-05 | Sequence: 1997-01-28

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2037	579582..581618	2010-01-05	1997-01-28

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000004972

CRZ1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CRZ1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CRZ1]

1)	Stathopoulos AM and Cyert MS (1997) Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast. Genes Dev 11(24):3432-44
2)	Matheos DP, et al. (1997) Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae. Genes Dev 11(24):3445-58
3)	Boustany LM and Cyert MS (2002) Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site. Genes Dev 16(5):608-19

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