CRD1/YDL142C Summary Help

CRD1 BASIC INFORMATION

Standard Name CRD1 1
Systematic Name YDL142C
Alias CLS1 2 , 3
Feature Type ORF, Verified
Description Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis (1, 4, 5, 6, 7)
Name Description CaRDiolipin synthase 1
GO Annotations All CRD1 GO evidence and references
    View Computational GO annotations for CRD1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Pathways
Mutant Phenotype All CRD1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions CRD1 All interactions details and references
15 total interaction(s) for 15 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
Genetic Interactions
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 7
  • Synthetic Lethality: 4
Sequence Information
ChrIV:202571 to 201720 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..852 202571..201720 1996-07-31 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000002301

CRD1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CRD1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
CLS1Nomenclature conflictCLS1 has been used in the literature to refer to both CRD1/YDL142C which encodes a cardiolipin synthase, and the genetic locus CLS1.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CRD1]

1) Jiang F, et al.  (1999) Cardiolipin synthase expression is essential for growth at elevated temperature and is regulated by factors affecting mitochondrial development. Mol Microbiol 31(1):373-9
2) Jiang F, et al.  (1997) Cardiolipin is not essential for the growth of Saccharomyces cerevisiae on fermentable or non-fermentable carbon sources. Mol Microbiol 26(3):481-91
3) Tuller G, et al.  (1998) YDL142c encodes cardiolipin synthase (Cls1p) and is non-essential for aerobic growth of Saccharomyces cerevisiae. FEBS Lett 421(1):15-8
4) Chang SC, et al.  (1998) Isolation and characterization of the gene (CLS1) encoding cardiolipin synthase in Saccharomyces cerevisiae. J Biol Chem 273(24):14933-41
5) Jiang F, et al.  (2000) Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function. J Biol Chem 275(29):22387-94
6) Zhang M, et al.  (2003) Cardiolipin is not required to maintain mitochondrial DNA stability or cell viability for Saccharomyces cerevisiae grown at elevated temperatures. J Biol Chem 278(37):35204-10
7) Chen S, et al.  (2008) Cardiolipin mediates cross-talk between mitochondria and the vacuole. Mol Biol Cell 19(12):5047-58