CPR7/YJR032W Summary Help

Standard Name CPR7
Systematic Name YJR032W
Feature Type ORF, Verified
Description Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; plays a role in determining prion variants (1, 2)
Name Description Cyclosporin-sensitive Proline Rotamase
Chromosomal Location
ChrX:491081 to 492262 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CPR7 GO evidence and references
  View Computational GO annotations for CPR7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 99 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
243 total interaction(s) for 152 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 16
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • Protein-RNA: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 120
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 1
  • Positive Genetic: 34
  • Synthetic Growth Defect: 21
  • Synthetic Lethality: 14
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 393
Molecular Weight (Da) 45,133
Isoelectric Point (pI) 5.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:491081 to 492262 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1182 491081..492262 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003793
References cited on this page View Complete Literature Guide for CPR7
1) Mayr C, et al.  (2000) Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties. J Biol Chem 275(44):34140-6
2) Lancaster DL, et al.  (2013) Chaperone proteins select and maintain [PIN+] prion conformations in Saccharomyces cerevisiae. J Biol Chem 288(2):1266-76