CPR7/YJR032W Summary Help

Standard Name CPR7
Systematic Name YJR032W
Feature Type ORF, Verified
Description Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; plays a role in determining prion variants (1, 2)
Name Description Cyclosporin-sensitive Proline Rotamase
Chromosomal Location
ChrX:491081 to 492262 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CPR7 GO evidence and references
  View Computational GO annotations for CPR7
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
244 total interaction(s) for 152 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 15
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 16
  • Biochemical Activity: 1
  • Co-fractionation: 1
  • Protein-RNA: 1
  • Reconstituted Complex: 4
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 120
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 1
  • Positive Genetic: 34
  • Synthetic Growth Defect: 21
  • Synthetic Lethality: 14
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 393
Molecular Weight (Da) 45,133
Isoelectric Point (pI) 5.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:491081 to 492262 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1182 491081..492262 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003793
References cited on this page View Complete Literature Guide for CPR7
1) Mayr C, et al.  (2000) Cpr6 and Cpr7, two closely related Hsp90-associated immunophilins from Saccharomyces cerevisiae, differ in their functional properties. J Biol Chem 275(44):34140-6
2) Lancaster DL, et al.  (2013) Chaperone proteins select and maintain [PIN+] prion conformations in Saccharomyces cerevisiae. J Biol Chem 288(2):1266-76