CPR5/YDR304C Summary Help

Standard Name CPR5
Systematic Name YDR304C
Alias CYP5
Feature Type ORF, Verified
Description Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; CPR5 has a paralog, CPR2, that arose from the whole genome duplication (1, 2, 3)
Name Description Cyclosporin-sensitive Proline Rotamase
Chromosomal Location
ChrIV:1072557 to 1071880 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CPR5 GO evidence and references
  View Computational GO annotations for CPR5
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
40 total interaction(s) for 36 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 12
  • Affinity Capture-RNA: 3
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 19
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Positive Genetic: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 225
Molecular Weight (Da) 25,327
Isoelectric Point (pI) 5.4
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:1072557 to 1071880 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..678 1072557..1071880 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002712
References cited on this page View Complete Literature Guide for CPR5
1) Dolinski K, et al.  (1997) All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(24):13093-8
2) Frigerio G and Pelham HR  (1993) A Saccharomyces cerevisiae cyclophilin resident in the endoplasmic reticulum. J Mol Biol 233(1):183-8
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61