CPR2/YHR057C Summary Help

Standard Name CPR2
Systematic Name YHR057C
Alias CYP2
Feature Type ORF, Verified
Description Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR2 has a paralog, CPR5, that arose from the whole genome duplication; suppresses toxicity of slow-folding human Z-type alpha1-antitrypsin variant associated with liver cirrhosis and emphysema (1, 2, 3, 4, 5)
Name Description Cyclosporin-sensitive Proline Rotamase
Chromosomal Location
ChrVIII:218843 to 218226 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CPR2 GO evidence and references
  View Computational GO annotations for CPR2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 8 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
19 total interaction(s) for 18 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 5
  • Two-hybrid: 3

Genetic Interactions
  • Negative Genetic: 7
  • Positive Genetic: 2
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 205
Molecular Weight (Da) 22,769
Isoelectric Point (pI) 6.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:218843 to 218226 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..618 218843..218226 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001099
References cited on this page View Complete Literature Guide for CPR2
1) Sykes K, et al.  (1993) Proline isomerases function during heat shock. Proc Natl Acad Sci U S A 90(12):5853-7
2) Dolinski K, et al.  (1997) All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(24):13093-8
3) Koser PL, et al.  (1991) The CYP2 gene of Saccharomyces cerevisiae encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase with an N-terminal signal sequence. Gene 108(1):73-80
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Jung CH, et al.  (2014) Retarded protein folding of the human Z-type a1-antitrypsin variant is suppressed by Cpr2p. Biochem Biophys Res Commun 445(1):191-5