CPR1/YDR155C Summary

CPR1 BASIC INFORMATION

Standard Name	CPR1 1
Systematic Name	YDR155C
Alias	CYP1 , CPH1 2
Feature Type	ORF, Verified
Description	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A (2, 3)
Name Description	Cyclosporin A-sensitive Proline Rotamase

GO Annotations	All CPR1 GO evidence and references
	View Computational GO annotations for CPR1
Molecular Function
Manually curated	cyclosporin A binding (IMP) peptidyl-prolyl cis-trans isomerase activity (IDA)
Biological Process
Manually curated	ascospore formation (IMP) cellular protein metabolic process (IMP) histone deacetylation (IDA) negative regulation of meiosis (IPI)
Cellular Component
Manually curated	histone deacetylase complex (IPI) nucleus (IDA) Set3 complex (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All CPR1 Phenotype details and references
Classical genetics
null	IME1 mRNA accumulation: decreased heat sensitivity: increased histone H3 modification: increased resistance to cyclosporin A: increased resistance to rapamycin: increased sporulation: decreased vegetative growth: absent viable
Large-scale survey
null	viable

Interactions	CPR1 All interactions details and references
	98 total interaction(s) for 67 unique genes/features.
Physical Interactions	Affinity Capture-MS: 58 Affinity Capture-RNA: 2 Affinity Capture-Western: 6 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 3 Phenotypic Enhancement: 12 Phenotypic Suppression: 3 Synthetic Growth Defect: 1 Synthetic Lethality: 5 Synthetic Rescue: 6

Sequence Information

ChrIV:768998 to 768510 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2008-06-05 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..489	768998..768510	2008-06-05	1996-07-31

External Links	All Associated Seq \| E.C. \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000002562

CPR1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for CPR1

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
NCP1	Nomenclature conflict	Both CPR1/YDR155C and NCP1/YHR042W have been referred to as CPR1.
HAP1	Nomenclature conflict	CYP1 has been used in the literature to refer to both HAP1/YLR256W, which encodes a RNA Pol II transcription factor, and CPR1/YDR155C, which encodes a peptidyl-prolyl cis-trans isomerase.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CPR1]

1)	Heitman J, et al. (1991) FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(5):1948-52
2)	Haendler B, et al. (1989) Yeast cyclophilin: isolation and characterization of the protein, cDNA and gene. Gene 83(1):39-46
3)	Dolinski K, et al. (1997) All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(24):13093-8

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