COX20/YDR231C Summary Help

Standard Name COX20 1
Systematic Name YDR231C
Feature Type ORF, Verified
Description Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase (1 and see Summary Paragraph)
Name Description Cytochrome c OXidase 1
Chromosomal Location
ChrIV:926910 to 926293 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All COX20 GO evidence and references
  View Computational GO annotations for COX20
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 11 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
22 total interaction(s) for 17 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 6
  • Protein-RNA: 1
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 205
Molecular Weight (Da) 23,758
Isoelectric Point (pI) 10.23
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIV:926910 to 926293 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..618 926910..926293 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000002639
SUMMARY PARAGRAPH for COX20

COX20 encodes a specific chaperone that facilitates proteolytic processing of the mitochondrial gene product Cox2p and its assembly into the mitochondrial inner membrane enzyme cytochrome c oxidase (1). Cox20p is required for N-terminal processing of Cox2p by the mitochondrial inner membrane peptidase (Imp1p, Imp2p, and Som1p), but is not required for processing of other inner membrane peptidase substrates (1) Physical interaction between Cox20p, which is an integral protein of the mitochondrial inner membrane, and Cox2p can be detected both before and after Cox2p N-terminal processing (1). The cox20 null mutant contains unprocessed Cox2p that is not assembled into cytochrome c oxidase, causing a respiratory growth defect due to lack of cytochrome c oxidase activity (1).

Last updated: 2002-12-04 Contact SGD

References cited on this page View Complete Literature Guide for COX20
1) Hell K, et al.  (2000) Identification of Cox20p, a novel protein involved in the maturation and assembly of cytochrome oxidase subunit 2. J Biol Chem 275(7):4571-8