COX17/YLL009C Summary Help

Standard Name COX17
Systematic Name YLL009C
Feature Type ORF, Verified
Description Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs (1, 2, 3, 4, 5)
Name Description Cytochrome c OXidase
Chromosomal Location
ChrXII:131414 to 131205 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All COX17 GO evidence and references
  View Computational GO annotations for COX17
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 4 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
Resources
27 total interaction(s) for 19 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 7
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Co-crystal Structure: 1
  • Co-purification: 1
  • Protein-peptide: 1
  • Protein-RNA: 2
  • Reconstituted Complex: 2

Genetic Interactions
  • Dosage Rescue: 3
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 69
Molecular Weight (Da) 8,056
Isoelectric Point (pI) 4.7
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:131414 to 131205 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..210 131414..131205 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003932
References cited on this page View Complete Literature Guide for COX17
1) Beers J, et al.  (1997) Purification, characterization, and localization of yeast Cox17p, a mitochondrial copper shuttle. J Biol Chem 272(52):33191-6
2) Heaton D, et al.  (2000) Mutational analysis of the mitochondrial copper metallochaperone Cox17. J Biol Chem 275(48):37582-7
3) Maxfield AB, et al.  (2004) Cox17 is functional when tethered to the mitochondrial inner membrane. J Biol Chem 279(7):5072-80
4) Horng YC, et al.  (2004) Specific copper transfer from the Cox17 metallochaperone to both Sco1 and Cox11 in the assembly of yeast cytochrome C oxidase. J Biol Chem 279(34):35334-40
5) Longen S, et al.  (2009) Systematic analysis of the twin cx(9)c protein family. J Mol Biol 393(2):356-68