COX17/YLL009C Summary

COX17 BASIC INFORMATION

Standard Name	COX17
Systematic Name	YLL009C
Feature Type	ORF, Verified
Description	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs (1, 2, 3, 4, 5)
Name Description	Cytochrome c OXidase

GO Annotations	All COX17 GO evidence and references
	View Computational GO annotations for COX17
Molecular Function
Manually curated	copper chaperone activity (IDA, IMP, IPI)
Biological Process
Manually curated	intracellular copper ion transport (IDA, IMP, IPI) mitochondrial respiratory chain complex IV assembly (IDA, IMP)
Cellular Component
Manually curated	cytosol (IDA) mitochondrial intermembrane space (IDA)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All COX17 Phenotype details and references
Classical genetics
null	alkaline pH resistance: decreased metal resistance: decreased cytochrome c oxidase activity: decreased cytochrome c reductase activity: decreased Cox2p accumulation: decreased Cyt1p accumulation: decreased
Large-scale survey
null	glycogen accumulation: decreased competitive fitness: decreased resistance to 2-phenyl-3-nitroso-imidazo[1,2-a]pyridine: decreased respiratory growth: decreased rate respiratory growth: absent viable
overexpression	filamentous growth: increased

Interactions	COX17 All interactions details and references
	16 total interaction(s) for 11 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Affinity Capture-Western: 1 Biochemical Activity: 1 Co-crystal Structure: 1 Protein-RNA: 2 Reconstituted Complex: 2
Genetic Interactions	Dosage Rescue: 3 Synthetic Growth Defect: 3 Synthetic Rescue: 1

Sequence Information

ChrXII:131413 to 131204 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1996-07-31 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..210	131413..131204	1996-07-31	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000003932

COX17 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for COX17

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for COX17]

1)	Beers J, et al. (1997) Purification, characterization, and localization of yeast Cox17p, a mitochondrial copper shuttle. J Biol Chem 272(52):33191-6
2)	Heaton D, et al. (2000) Mutational analysis of the mitochondrial copper metallochaperone Cox17. J Biol Chem 275(48):37582-7
3)	Maxfield AB, et al. (2004) Cox17 is functional when tethered to the mitochondrial inner membrane. J Biol Chem 279(7):5072-80
4)	Horng YC, et al. (2004) Specific copper transfer from the Cox17 metallochaperone to both Sco1 and Cox11 in the assembly of yeast cytochrome C oxidase. J Biol Chem 279(34):35334-40
5)	Longen S, et al. (2009) Systematic analysis of the twin cx(9)c protein family. J Mol Biol 393(2):356-68

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