COX1/Q0045 Summary Help

Standard Name COX1
Systematic Name Q0045
Alias OXI3
Feature Type ORF, Verified
Description Subunit I of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits (1 and see Summary Paragraph)
Name Description Cytochrome c OXidase
Chromosomal Location
ChrMito:13818 to 26701 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All COX1 GO evidence and references
  View Computational GO annotations for COX1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Pathways
Classical genetics
null
Resources
72 total interaction(s) for 43 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 5
  • Affinity Capture-Western: 38
  • Co-fractionation: 9
  • Co-purification: 3
  • Protein-RNA: 1

Genetic Interactions
  • Dosage Rescue: 4
  • Synthetic Lethality: 9
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 534
Molecular Weight (Da) 58,798
Isoelectric Point (pI) 7.12
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrMito:13818 to 26701 | ORF Map | GBrowse
This feature contains embedded feature(s): AI1 | AI2 | AI3 | AI4 | AI5_ALPHA | AI5_BETA
SGD ORF map
Last Update Coordinates: 2000-05-19 | Sequence: 2000-05-19
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..169 13818..13986 2000-05-19 2000-05-19
Intron 170..2617 13987..16434 2000-05-19 2000-05-19
CDS 2618..2653 16435..16470 2000-05-19 2000-05-19
Intron 2654..5136 16471..18953 2000-05-19 2000-05-19
CDS 5137..5174 18954..18991 2000-05-19 2000-05-19
Intron 5175..6690 18992..20507 2000-05-19 2000-05-19
CDS 6691..7167 20508..20984 2000-05-19 2000-05-19
Intron 7168..8177 20985..21994 2000-05-19 2000-05-19
CDS 8178..8429 21995..22246 2000-05-19 2000-05-19
Intron 8430..9794 22247..23611 2000-05-19 2000-05-19
CDS 9795..9929 23612..23746 2000-05-19 2000-05-19
Intron 9930..11500 23747..25317 2000-05-19 2000-05-19
CDS 11501..11525 25318..25342 2000-05-19 2000-05-19
Intron 11526..12411 25343..26228 2000-05-19 2000-05-19
CDS 12412..12884 26229..26701 2000-05-19 2000-05-19
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007260
SUMMARY PARAGRAPH for COX1

Cytochrome c oxidase catalyzes the terminal step in the electron transport chain involved in cellular respiration. This multisubunit enzyme of the mitochondrial inner membrane, also known as Complex IV, is composed of three core subunits encoded by the mitochondrial genome (Cox1p, Cox2p, and Cox3p) and eight additional subunits encoded by nuclear genes (Cox4p, Cox5Ap or Cox5Bp, Cox6p, Cox7p, Cox8p, Cox9p, Cox12p, and Cox13p) (1, 2, 3). The phenotype of a mutation affecting any of the genes encoding cytochrome c oxidase subunits, or any of the multiple genes required for expression or assembly of the subunits (reviewed in 4), is a decrease or block in respiratory growth. The inability to respire is not lethal since S. cerevisiae can grow by fermentation, but nonrespiring cells grow more slowly than respiratory-competent cells even on glucose-containing medium, resulting in smaller colony size. Such mutations causing "petite" colonies were first described by Ephrussi and colleagues around 1950 (5).

Last updated: 2006-08-18 Contact SGD

References cited on this page View Complete Literature Guide for COX1
1) Taanman JW and Capaldi RA  (1992) Purification of yeast cytochrome c oxidase with a subunit composition resembling the mammalian enzyme. J Biol Chem 267(31):22481-5
2) Geier BM, et al.  (1995) Kinetic properties and ligand binding of the eleven-subunit cytochrome-c oxidase from Saccharomyces cerevisiae isolated with a novel large-scale purification method. Eur J Biochem 227(1-2):296-302
3) Cooper CE, et al.  (1991) Cytochrome c oxidase: structure, function, and membrane topology of the polypeptide subunits. Biochem Cell Biol 69(9):586-607
4) Herrmann JM and Funes S  (2005) Biogenesis of cytochrome oxidase-sophisticated assembly lines in the mitochondrial inner membrane. Gene 354():43-52
5) Ephrussi B and Slonimski PP  (1955) Subcellular units involved in the synthesis of respiratory enzymes in yeast. Nature 176(4495):1207-8