COQ8/YGL119W Summary Help

Standard Name COQ8 1
Systematic Name YGL119W
Alias ABC1 2
Feature Type ORF, Verified
Description Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication (2, 3, 4, 5, 6)
Name Description COenzyme Q 1
Chromosomal Location
ChrVII:284442 to 285947 | ORF Map | GBrowse
Gene Ontology Annotations All COQ8 GO evidence and references
  View Computational GO annotations for COQ8
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
reduction of function
Large-scale survey
66 total interaction(s) for 53 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
  • Biochemical Activity: 2
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 26
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 9
  • Positive Genetic: 15

Expression Summary
Length (a.a.) 501
Molecular Weight (Da) 56,741
Isoelectric Point (pI) 10.12
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:284442 to 285947 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1506 284442..285947 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003087
References cited on this page View Complete Literature Guide for COQ8
1) Tzagoloff A and Dieckmann CL  (1990) PET genes of Saccharomyces cerevisiae. Microbiol Rev 54(3):211-25
2) Bousquet I, et al.  (1991) ABC1, a novel yeast nuclear gene has a dual function in mitochondria: it suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex. EMBO J 10(8):2023-31
3) Poon WW, et al.  (2000) Identification of Escherichia coli ubiB, a gene required for the first monooxygenase step in ubiquinone biosynthesis. J Bacteriol 182(18):5139-46
4) Do TQ, et al.  (2001) A defect in coenzyme Q biosynthesis is responsible for the respiratory deficiency in Saccharomyces cerevisiae abc1 mutants. J Biol Chem 276(21):18161-8
5) Johnson A, et al.  (2005) COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae. J Biol Chem 280(36):31397-404
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61