Standard Name	COG5 1
Systematic Name	YNL051W
Alias	API4 2 , COD4
Feature Type	ORF, Verified
Description	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments (1, 3)
Name Description	Conserved Oligomeric Golgi complex 1

Chromosomal Location	ChrXIV:532659 to 533870 | ORF Map | GBrowse

	View Computational GO annotations for COG5
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	CVT pathway (IMP) intra-Golgi vesicle-mediated transport (IGI, IPI)
Cellular Component
Manually curated	Golgi transport complex (IPI)

Classical genetics
reduction of function	Ape1p (API) modification: decreased
Large-scale survey
null	auxotrophy rubidium(1+) accumulation: decreased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased heat sensitivity: increased hyperosmotic stress resistance: decreased metal resistance: decreased resistance to (S)-lactic acid: decreased resistance to ethanol: decreased resistance to PM02734: decreased resistance to hygromycin B: decreased resistance to methyl methanesulfonate: increased resistance to fluconazole: increased resistance to fenpropimorph: increased resistance to camptothecin: increased resistance to cycloheximide: decreased resistance to amitrole: decreased resistance to paromomycin: decreased resistance to spermine: decreased resistance to bleomycin: decreased resistance to caffeine: decreased resistance to hydroxyurea: decreased resistance to mycophenolic acid: decreased resistance to sirolimus: decreased resistance to tunicamycin: decreased resistance to ciclopirox olamine: decreased resistance to clioquinol: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased resistance to acrolein: decreased vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	604 total interaction(s) for 261 unique genes/features.
Physical Interactions	Affinity Capture-MS: 25 Affinity Capture-Western: 11 Two-hybrid: 5
Genetic Interactions	Negative Genetic: 441 Phenotypic Enhancement: 62 Phenotypic Suppression: 6 Positive Genetic: 27 Synthetic Growth Defect: 16 Synthetic Lethality: 11
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrXIV:532659 to 533870 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1997-01-28
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1212 532659..533870 2011-02-03 1997-01-28
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000004996