Standard Name	COG3 1
Systematic Name	YER157W
Alias	GRD20 , SEC34
Feature Type	ORF, Verified
Description	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments (1, 2)
Name Description	Conserved Oligomeric Golgi complex 3

Chromosomal Location	ChrV:484788 to 487193 | ORF Map | GBrowse

	View Computational GO annotations for COG3
Molecular Function
Manually curated	protein transporter activity (TAS)
Biological Process
Manually curated	CVT pathway (IMP) ER to Golgi vesicle-mediated transport (IGI) intra-Golgi vesicle-mediated transport (IGI, IPI) macroautophagy (IMP) peroxisome degradation (IMP) retrograde transport, vesicle recycling within Golgi (IMP, TAS)
Cellular Component
Manually curated	Golgi transport complex (IPI)

Classical genetics
conditional	Kex2 secretion: abnormal vacuolar transport: abnormal
null	resistance to nelfinavir: decreased vegetative growth: decreased rate viable
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable toxin resistance: decreased
reduction of function	telomere length: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	317 total interaction(s) for 243 unique genes/features.
Physical Interactions	Affinity Capture-MS: 26 Affinity Capture-Western: 18 Biochemical Activity: 1 Co-fractionation: 2 Co-localization: 2 PCA: 9 Reconstituted Complex: 2 Two-hybrid: 30
Genetic Interactions	Dosage Rescue: 17 Negative Genetic: 154 Positive Genetic: 40 Synthetic Growth Defect: 4 Synthetic Lethality: 12
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrV:484788 to 487193 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2406 484788..487193 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000000959