COG3/YER157W Summary Help

Standard Name COG3 1
Systematic Name YER157W
Alias GRD20 2 , SEC34
Feature Type ORF, Verified
Description Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments (1, 3)
Name Description Conserved Oligomeric Golgi complex 1
Chromosomal Location
ChrV:484788 to 487193 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All COG3 GO evidence and references
  View Computational GO annotations for COG3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
reduction of function
Resources
320 total interaction(s) for 243 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 27
  • Affinity Capture-Western: 18
  • Biochemical Activity: 1
  • Co-fractionation: 2
  • Co-localization: 2
  • PCA: 9
  • Reconstituted Complex: 2
  • Two-hybrid: 30

Genetic Interactions
  • Dosage Rescue: 17
  • Negative Genetic: 156
  • Positive Genetic: 40
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 12

Resources
Expression Summary
histogram
Resources
Length (a.a.) 801
Molecular Weight (Da) 92,543
Isoelectric Point (pI) 5.16
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrV:484788 to 487193 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2406 484788..487193 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000000959
References cited on this page View Complete Literature Guide for COG3
1) Ram RJ, et al.  (2002) Identification of Sec36p, Sec37p, and Sec38p: components of yeast complex that contains Sec34p and Sec35p. Mol Biol Cell 13(5):1484-500
2) Spelbrink RG and Nothwehr SF  (1999) The yeast GRD20 gene is required for protein sorting in the trans-Golgi network/endosomal system and for polarization of the actin cytoskeleton. Mol Biol Cell 10(12):4263-81
3) Loh E and Hong W  (2004) The binary interacting network of the conserved oligomeric Golgi tethering complex. J Biol Chem 279(23):24640-8