COG2/YGR120C Summary Help

Standard Name COG2 1
Systematic Name YGR120C
Alias SEC35
Feature Type ORF, Verified
Description Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; the components of the Golgi complex are Gog1p through Cog8p (1, 2)
Name Description Conserved Oligomeric Golgi complex 1
Chromosomal Location
ChrVII:730821 to 730033 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All COG2 GO evidence and references
  View Computational GO annotations for COG2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
reduction of function
Resources
187 total interaction(s) for 90 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 34
  • Co-fractionation: 2
  • PCA: 1
  • Reconstituted Complex: 6
  • Two-hybrid: 47

Genetic Interactions
  • Dosage Rescue: 16
  • Negative Genetic: 41
  • Phenotypic Enhancement: 1
  • Positive Genetic: 2
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 8

Resources
Expression Summary
histogram
Resources
Length (a.a.) 262
Molecular Weight (Da) 30,325
Isoelectric Point (pI) 4.34
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:730821 to 730033 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2003-09-22
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..789 730821..730033 2011-02-03 2003-09-22
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003352
References cited on this page View Complete Literature Guide for COG2
1) Ram RJ, et al.  (2002) Identification of Sec36p, Sec37p, and Sec38p: components of yeast complex that contains Sec34p and Sec35p. Mol Biol Cell 13(5):1484-500
2) Loh E and Hong W  (2004) The binary interacting network of the conserved oligomeric Golgi tethering complex. J Biol Chem 279(23):24640-8