COA6/YMR244C-A Summary Help

Standard Name COA6 1
Systematic Name YMR244C-A
Feature Type ORF, Verified
Description Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description Cytochrome Oxidase Assembly 1
Chromosomal Location
ChrXIII:758831 to 758517 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All COA6 GO evidence and references
  View Computational GO annotations for COA6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
21 total interaction(s) for 20 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 2
  • Co-purification: 1

Genetic Interactions
  • Negative Genetic: 16
  • Positive Genetic: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 104
Molecular Weight (Da) 12,445
Isoelectric Point (pI) 9.31
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXIII:758831 to 758517 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..315 758831..758517 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004857
References cited on this page View Complete Literature Guide for COA6
1) Voegtle FN, et al.  (2012) Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics 11(12):1840-52
2) Lee MW, et al.  (2007) Global protein expression profiling of budding yeast in response to DNA damage. Yeast 24(3):145-54
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
4) Ghosh A, et al.  (2014) Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency. Hum Mol Genet 23(13):3596-606