COA3/YJL062W-A Summary Help

Standard Name COA3 1
Systematic Name YJL062W-A
Alias RRG10 2 , COX25 3
Feature Type ORF, Verified
Description Mitochondrial protein required for cytochrome c oxidase assembly; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; located in the mitochondrial inner membrane (1, 2, 3, 4, 5)
Name Description Cytochrome Oxidase Assembly 1
Chromosomal Location
ChrX:316723 to 316980 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All COA3 GO evidence and references
  View Computational GO annotations for COA3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
33 total interaction(s) for 17 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 21

Genetic Interactions
  • Phenotypic Suppression: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 85
Molecular Weight (Da) 9,881
Isoelectric Point (pI) 10.21
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrX:316723 to 316980 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2001-02-26
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..258 316723..316980 2011-02-03 2001-02-26
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000007611
References cited on this page View Complete Literature Guide for COA3
1) Mick DU, et al.  (2010) Coa3 and Cox14 are essential for negative feedback regulation of COX1 translation in mitochondria. J Cell Biol 191(1):141-54
2) Merz S and Westermann B  (2009) Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Genome Biol 10(9):R95
3) Fontanesi F, et al.  (2011) Cox25 Teams Up with Mss51, Ssc1, and Cox14 to Regulate Mitochondrial Cytochrome c Oxidase Subunit 1 Expression and Assembly in Saccharomyces cerevisiae. J Biol Chem 286(1):555-66
4) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
5) McStay GP, et al.  (2013) Stabilization of Cox1p intermediates by the Cox14p-Coa3p complex. FEBS Lett 587(7):943-9