CNE1/YAL058W Summary Help

CNE1 BASIC INFORMATION

Standard Name CNE1
Systematic Name YAL058W
Alias FUN48
Feature Type ORF, Verified
Description Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast (1, 2, 3, 4)
Name Description CalNExin and calreticulin homolog
GO Annotations All CNE1 GO evidence and references
    View Computational GO annotations for CNE1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All CNE1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions CNE1 All interactions details and references
51 total interaction(s) for 29 unique genes/features.
Physical Interactions
  • Two-hybrid: 1
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 40
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 6
Sequence Information
ChrI:37465 to 38973 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1996-07-31 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1509 37465..38973 1996-07-31 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000000054

CNE1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Literature
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  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for CNE1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CNE1]

1) Parlati F, et al.  (1995) Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus. J Biol Chem 270(1):244-53
2) Xu X, et al.  (2004) Expression and characterization of Saccharomyces cerevisiae Cne1p, a calnexin homologue. J Biochem 135(5):615-8
3) Xu X, et al.  (2004) P-domain and lectin site are involved in the chaperone function of Saccharomyces cerevisiae calnexin homologue. FEBS Lett 570(1-3):155-60
4) Kimura T, et al.  (2005) Interactions among Yeast Protein-Disulfide Isomerase Proteins and Endoplasmic Reticulum Chaperone Proteins Influence Their Activities. J Biol Chem 280(36):31438-41