CNA1/YLR433C Summary Help

CNA1 BASIC INFORMATION

Standard Name CNA1 1
Systematic Name YLR433C
Alias CMP1 2
Feature Type ORF, Verified
Description Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 (3, 4, 5)
Name Description CalciNeurin A 1
GO Annotations All CNA1 GO evidence and references
    View Computational GO annotations for CNA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: stressResponse ( 637 , 541 , 397 )
Mutant Phenotype All CNA1 Phenotype details and references
Classical genetics
null
unspecified
Large-scale survey
null
Interactions CNA1 All interactions details and references
43 total interaction(s) for 26 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • Co-purification: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 17
Genetic Interactions
  • Dosage Rescue: 6
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 1
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 3
Sequence Information
ChrXII:1006005 to 1004344 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2006-01-09 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1662 1006005..1004344 2006-01-09 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000004425

CNA1 RESOURCES

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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for CNA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for CNA1]

1) Cyert MS, et al.  (1991) Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase. Proc Natl Acad Sci U S A 88(16):7376-80
2) Liu Y, et al.  (1991) The Saccharomyces cerevisiae genes (CMP1 and CMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B. Mol Gen Genet 227(1):52-9
3) Garrett-Engele P, et al.  (1995) Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase. Mol Cell Biol 15(8):4103-14
4) Cyert MS  (2003) Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress. Biochem Biophys Res Commun 311(4):1143-50
5) Rusnak F and Mertz P  (2000) Calcineurin: form and function. Physiol Rev 80(4):1483-521