CNA1/YLR433C Summary Help

Standard Name CNA1 1
Systematic Name YLR433C
Alias CMP1 2
Feature Type ORF, Verified
Description Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog, CMP2, that arose from the whole genome duplication (3, 4, 5, 6, 7)
Name Description CalciNeurin A 1
Chromosomal Location
ChrXII:1006008 to 1004347 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CNA1 GO evidence and references
  View Computational GO annotations for CNA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
Resources
95 total interaction(s) for 65 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 25
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 4
  • Biochemical Activity: 3
  • Co-crystal Structure: 1
  • Co-purification: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 19

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 6
  • Negative Genetic: 20
  • Positive Genetic: 2
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 3
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 553
Molecular Weight (Da) 63,001
Isoelectric Point (pI) 6.65
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXII:1006008 to 1004347 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1662 1006008..1004347 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000004425
References cited on this page View Complete Literature Guide for CNA1
1) Cyert MS, et al.  (1991) Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase. Proc Natl Acad Sci U S A 88(16):7376-80
2) Liu Y, et al.  (1991) The Saccharomyces cerevisiae genes (CMP1 and CMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B. Mol Gen Genet 227(1):52-9
3) Garrett-Engele P, et al.  (1995) Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase. Mol Cell Biol 15(8):4103-14
4) Cyert MS  (2003) Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stress. Biochem Biophys Res Commun 311(4):1143-50
5) Rusnak F and Mertz P  (2000) Calcineurin: form and function. Physiol Rev 80(4):1483-521
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7) O'Donnell AF, et al.  (2013) A Calcineurin-dependent Switch Controls the Trafficking Function of a-Arrestin Aly1/Art6. J Biol Chem 288(33):24063-80