Standard Name	CMK1 1, 2
Systematic Name	YFR014C
Feature Type	ORF, Verified
Description	Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	CalModulin dependent protein Kinase 1, 2

Chromosomal Location	ChrVI:173877 to 172537 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for CMK1
Molecular Function
Manually curated	calmodulin-dependent protein kinase activity (IDA)
High-throughput	protein kinase activity (IDA)
Biological Process
Manually curated	protein phosphorylation (IDA) signal transduction (IMP)
High-throughput	protein phosphorylation (IDA)
Cellular Component
Manually curated	cytoplasm (IPI)

Regulatory modules	predicted: stressResponse (619, 583, 505, 361)

Classical genetics
null	toxin resistance: decreased
Large-scale survey
null	competitive fitness: increased haploproficient resistance to benzo[a]pyrene: decreased toxin resistance: decreased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	270 total interaction(s) for 254 unique genes/features.
Physical Interactions	Affinity Capture-MS: 10 Affinity Capture-RNA: 1 Biochemical Activity: 158 Reconstituted Complex: 30
Genetic Interactions	Dosage Growth Defect: 15 Negative Genetic: 43 Phenotypic Suppression: 1 Positive Genetic: 8 Synthetic Growth Defect: 3 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVI:173877 to 172537 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1341 173877..172537 2011-02-03 2011-02-03
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001910