CMK1/YFR014C Summary Help

Standard Name CMK1 1, 2
Systematic Name YFR014C
Feature Type ORF, Verified
Description Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description CalModulin dependent protein Kinase 1, 2
Chromosomal Location
ChrVI:173877 to 172537 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All CMK1 GO evidence and references
  View Computational GO annotations for CMK1
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
High-throughput
Cellular Component
Manually curated
Regulators 1 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
250 total interaction(s) for 233 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 11
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 158
  • Reconstituted Complex: 30

Genetic Interactions
  • Dosage Growth Defect: 15
  • Dosage Rescue: 1
  • Negative Genetic: 19
  • Phenotypic Suppression: 1
  • Positive Genetic: 9
  • Synthetic Growth Defect: 3
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 446
Molecular Weight (Da) 50,296
Isoelectric Point (pI) 6.01
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVI:173877 to 172537 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1341 173877..172537 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001910
References cited on this page View Complete Literature Guide for CMK1
1) Pausch MH, et al.  (1991) Multiple Ca2+/calmodulin-dependent protein kinase genes in a unicellular eukaryote. EMBO J 10(6):1511-22
2) Ohya Y, et al.  (1991) Two yeast genes encoding calmodulin-dependent protein kinases. Isolation, sequencing and bacterial expressions of CMK1 and CMK2. J Biol Chem 266(19):12784-94
3) Cyert MS  (2001) Genetic analysis of calmodulin and its targets in Saccharomyces cerevisiae. Annu Rev Genet 35:647-72
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61