CLC1/YGR167W Summary Help

Standard Name CLC1 1
Systematic Name YGR167W
Alias SCD4 2 , 3
Feature Type ORF, Verified
Description Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion (1, 3, 4, 5, 6, 7, 8, 9)
Name Description Clathrin Light Chain 1
Chromosomal Location
ChrVII:832456 to 833157 | ORF Map | GBrowse
Gene Ontology Annotations All CLC1 GO evidence and references
  View Computational GO annotations for CLC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
450 total interaction(s) for 398 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 24
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 18
  • Biochemical Activity: 5
  • Reconstituted Complex: 8
  • Two-hybrid: 6

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 313
  • Phenotypic Suppression: 6
  • Positive Genetic: 56
  • Synthetic Growth Defect: 1
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 5

Expression Summary
Length (a.a.) 233
Molecular Weight (Da) 26,531
Isoelectric Point (pI) 4.15
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVII:832456 to 833157 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..702 832456..833157 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003399
References cited on this page View Complete Literature Guide for CLC1
1) Silveira LA, et al.  (1990) Yeast clathrin has a distinctive light chain that is important for cell growth. J Cell Biol 111(4):1437-49
2) Nelson KK and Lemmon SK  (1993) Suppressors of clathrin deficiency: overexpression of ubiquitin rescues lethal strains of clathrin-deficient Saccharomyces cerevisiae. Mol Cell Biol 13(1):521-32
3) Huang KM, et al.  (1997) Novel functions of clathrin light chains: clathrin heavy chain trimerization is defective in light chain-deficient yeast. J Cell Sci 110 ( Pt 7):899-910
4) Lemmon SK and Jones EW  (1987) Clathrin requirement for normal growth of yeast. Science 238(4826):504-9
5) Chu DS, et al.  (1999) A modulatory role for clathrin light chain phosphorylation in Golgi membrane protein localization during vegetative growth and during the mating response of Saccharomyces cerevisiae. Mol Biol Cell 10(3):713-26
6) Chu DS, et al.  (1996) The light chain subunit is required for clathrin function in Saccharomyces cerevisiae. J Biol Chem 271(51):33123-30
7) Kirchhausen T  (2000) Three ways to make a vesicle. Nat Rev Mol Cell Biol 1(3):187-98
8) Boettner DR, et al.  (2011) Clathrin light chain directs endocytosis by influencing the binding of the yeast Hip1R homologue, Sla2, to F-actin. Mol Biol Cell 22(19):3699-714
9) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76