CLC1/YGR167W Summary Help

Standard Name CLC1 1
Systematic Name YGR167W
Alias SCD4 2 , 3
Feature Type ORF, Verified
Description Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W (1, 3, 4, 5, 6, 7)
Name Description Clathrin Light Chain 1
Chromosomal Location
ChrVII:832456 to 833157 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CLC1 GO evidence and references
  View Computational GO annotations for CLC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant phenotypes All CLC1 Phenotype evidence and references
Classical genetics
null
Large-scale survey
null
overexpression
Resources
interactions All CLC1 Interaction evidence and references
442 total interaction(s) for 398 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 22
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 18
  • Biochemical Activity: 5
  • Reconstituted Complex: 8
  • Two-hybrid: 6
Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 308
  • Phenotypic Suppression: 6
  • Positive Genetic: 55
  • Synthetic Growth Defect: 1
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 5
Resources
Expression Summary
histogram
Resources
Protein Information All CLC1 Protein evidence and references
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVII:832456 to 833157 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..702 832456..833157 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000003399
References cited on this page View Complete Literature Guide for CLC1
1) Silveira LA, et al.  (1990) Yeast clathrin has a distinctive light chain that is important for cell growth. J Cell Biol 111(4):1437-49
2) Nelson KK and Lemmon SK  (1993) Suppressors of clathrin deficiency: overexpression of ubiquitin rescues lethal strains of clathrin-deficient Saccharomyces cerevisiae. Mol Cell Biol 13(1):521-32
3) Huang KM, et al.  (1997) Novel functions of clathrin light chains: clathrin heavy chain trimerization is defective in light chain-deficient yeast. J Cell Sci 110 ( Pt 7):899-910
4) Chu DS, et al.  (1999) A modulatory role for clathrin light chain phosphorylation in Golgi membrane protein localization during vegetative growth and during the mating response of Saccharomyces cerevisiae. Mol Biol Cell 10(3):713-26
5) Chu DS, et al.  (1996) The light chain subunit is required for clathrin function in Saccharomyces cerevisiae. J Biol Chem 271(51):33123-30
6) Kirchhausen T  (2000) Three ways to make a vesicle. Nat Rev Mol Cell Biol 1(3):187-98
7) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76