CKB2/YOR039W Summary Help

Standard Name CKB2
Systematic Name YOR039W
Feature Type ORF, Verified
Description Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase (1, 2, 3)
Name Description Casein Kinase Beta' subunit
Gene Product Alias CK2 subunit 4
Chromosomal Location
ChrXV:405768 to 406544 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CKB2 GO evidence and references
  View Computational GO annotations for CKB2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Classical genetics
null
Large-scale survey
null
overexpression
Resources
479 total interaction(s) for 269 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 104
  • Affinity Capture-RNA: 3
  • Affinity Capture-Western: 9
  • Biochemical Activity: 11
  • Co-purification: 1
  • PCA: 5
  • Reconstituted Complex: 4
  • Two-hybrid: 5

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 2
  • Negative Genetic: 251
  • Phenotypic Enhancement: 5
  • Phenotypic Suppression: 1
  • Positive Genetic: 44
  • Synthetic Growth Defect: 27
  • Synthetic Lethality: 4
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 258
Molecular Weight (Da) 29,842
Isoelectric Point (pI) 5.94
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXV:405768 to 406544 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2006-01-05 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..777 405768..406544 2006-01-05 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000005565
References cited on this page View Complete Literature Guide for CKB2
1) Bidwai AP, et al.  (1994) Casein kinase II of Saccharomyces cerevisiae contains two distinct regulatory subunits, beta and beta'. Arch Biochem Biophys 309(2):348-55
2) Ackermann K, et al.  (2001) Genes targeted by protein kinase CK2: a genome-wide expression array analysis in yeast. Mol Cell Biochem 227(1-2):59-66
3) Ahmed K, et al.  (2002) Joining the cell survival squad: an emerging role for protein kinase CK2. Trends Cell Biol 12(5):226-30
4) Reed JC, et al.  (1994) Cloning and disruption of CKB2, the gene encoding the 32-kDa regulatory beta'-subunit of Saccharomyces cerevisiae casein kinase II. J Biol Chem 269(27):18192-200